Product Overview

Silica Gel 200-400 mesh For Column Chromatography (CAS No. 112926-00-8) is a fine-particle porous silica adsorbent intended for normal-phase packed-column separations. The silanol-rich surface provides strong polar adsorption, while the finer particle range increases the interfacial contact and generally supports more efficient mass transfer than substantially coarser column silica, although with correspondingly greater resistance to solvent flow. The submitted product is additionally designated as suitable to be used as Silica Gel 230-400 mesh For Column Chromatography.

The fine-particle product form is suited to higher-resolution preparative work and controlled-flow chromatographic columns where finer silica packing is methodologically appropriate. It is suitable to be used as Silica Gel 230-400 mesh For Column Chromatography, as the majority particle size of Silica Gel 200-400 mesh For Column Chromatography lies in the range of 230-400 mesh size.

Typical Applications

• Fine-particle preparative normal-phase column chromatography.
• Higher-resolution purification of closely retained organic compounds.
• Controlled-flow separation of reaction mixtures and natural-product fractions.
• Adsorptive cleanup requiring greater stationary-phase contact.
• Method development using fine silica packing.
• Applications requiring Silica Gel 230-400 mesh where the submitted product specification permits its use.

Common Synonyms

• 200-400 mesh silica gel
• Chromatographic silica gel
• Amorphous silica gel
• Silica gel

Storage Conditions

Store tightly closed and dry because moisture adsorption can alter silica activity and chromatographic selectivity. Protect the fine powder from organic vapours, particulate contamination and chemical residues, and maintain clean handling to avoid introducing impurities into packed columns.